Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs

Progress in oligonucleotide chemistry has produced a shift in the nature of siRNA used, from formulated, minimally modified siRNAs, to unformulated, heavily modified siRNA conjugates. The introduction of extensive chemical modifications is essential for conjugate-mediated delivery. Modifications hav...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Shmushkovich, Taisia, Monopoli, Kathryn R, Homsy, Diana, Leyfer, Dmitriy, Betancur-Boissel, Monica, Khvorova, Anastasia, Wolfson, Alexey D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237813/
https://ncbi.nlm.nih.gov/pubmed/30169779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky745
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