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A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1
GEN1 is a member of the FEN/EXO family of structure-selective nucleases that cleave 1 nt 3′ to a variety of branchpoints. For each, the H2TH motif binds a monovalent ion and plays an important role in binding one helical arm of the substrates. We investigate here the importance of this metal ion on...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237754/ https://ncbi.nlm.nih.gov/pubmed/30247722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky863 |
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