Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction

Irritable bowel syndrome (IBS) patients suffer from chronic abdominal pain and extraintestinal comorbidities, including overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC-PBS). Mechanistic understanding of the cause and time course of these comorbid symptoms is lacking,...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Grundy, Luke, Harrington, Andrea M., Castro, Joel, Garcia-Caraballo, Sonia, Deiteren, Annemie, Maddern, Jessica, Rychkov, Grigori Y., Ge, Pei, Peters, Stefanie, Feil, Robert, Miller, Paul, Ghetti, Andre, Hannig, Gerhard, Kurtz, Caroline B., Silos-Santiago, Inmaculada, Brierley, Stuart M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237488/
https://ncbi.nlm.nih.gov/pubmed/30282832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121841
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