Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function

Patients with diabetes are at significantly higher risk of developing heart failure. Increases in advanced glycation end products are a proposed pathophysiological link, but their impact and mechanism remain incompletely understood. Methylglyoxal (MG) is a glycolysis byproduct, elevated in diabetes,...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Papadaki, Maria, Holewinski, Ronald J., Previs, Samantha Beck, Martin, Thomas G., Stachowski, Marisa J., Li, Amy, Blair, Cheavar A., Moravec, Christine S., Van Eyk, Jennifer E., Campbell, Kenneth S., Warshaw, David M., Kirk, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237482/
https://ncbi.nlm.nih.gov/pubmed/30333300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121264
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