IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Tumors evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function(1–4). However, it remains unclear how intratumoral T cells integrate and interpret metabolic stress signals. Here we report that ovarian cancer (OvCa), an aggressive malignancy refr...

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Pubblicato in:Nature
Autori principali: Song, Minkyung, Sandoval, Tito A., Chae, Chang-Suk, Chopra, Sahil, Tan, Chen, Rutkowski, Melanie R., Raundhal, Mahesh, Chaurio, Ricardo A., Payne, Kyle K., Konrad, Csaba, Bettigole, Sarah E., Shin, Hee Rae, Crowley, Michael J. P., Cerliani, Juan P., Kossenkov, Andrew V., Motorykin, Ievgen, Zhang, Sheng, Manfredi, Giovanni, Zamarin, Dmitriy, Holcomb, Kevin, Rodriguez, Paulo C., Rabinovich, Gabriel A., Conejo-Garcia, Jose R., Glimcher, Laurie H., Cubillos-Ruiz, Juan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237282/
https://ncbi.nlm.nih.gov/pubmed/30305738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0597-x
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