IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Tumors evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function(1–4). However, it remains unclear how intratumoral T cells integrate and interpret metabolic stress signals. Here we report that ovarian cancer (OvCa), an aggressive malignancy refr...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Song, Minkyung, Sandoval, Tito A., Chae, Chang-Suk, Chopra, Sahil, Tan, Chen, Rutkowski, Melanie R., Raundhal, Mahesh, Chaurio, Ricardo A., Payne, Kyle K., Konrad, Csaba, Bettigole, Sarah E., Shin, Hee Rae, Crowley, Michael J. P., Cerliani, Juan P., Kossenkov, Andrew V., Motorykin, Ievgen, Zhang, Sheng, Manfredi, Giovanni, Zamarin, Dmitriy, Holcomb, Kevin, Rodriguez, Paulo C., Rabinovich, Gabriel A., Conejo-Garcia, Jose R., Glimcher, Laurie H., Cubillos-Ruiz, Juan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237282/
https://ncbi.nlm.nih.gov/pubmed/30305738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0597-x
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