ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

Dendritic cells (DCs) are required to initiate and sustain T cell-dependent anti-cancer immunity. However, tumors often evade immune control by crippling normal DC function. The endoplasmic reticulum (ER) stress response factor XBP1 promotes intrinsic tumor growth directly, but whether it also regul...

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Udgivet i:Cell
Main Authors: Cubillos-Ruiz, Juan R., Silberman, Pedro C., Rutkowski, Melanie R., Chopra, Sahil, Perales-Puchalt, Alfredo, Song, Minkyung, Zhang, Sheng, Bettigole, Sarah E., Gupta, Divya, Holcomb, Kevin, Ellenson, Lora H., Caputo, Thomas, Lee, Ann-Hwee, Conejo-Garcia, Jose R., Glimcher, Laurie H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580135/
https://ncbi.nlm.nih.gov/pubmed/26073941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.05.025
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