Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Dini, Leonardo, Del Lungo, Martina, Resta, Francesco, Melchiorre, Michele, Spinelli, Valentina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Laurino, Annunziatina, Sartiani, Laura, Coppini, Raffaele, Mannaioni, Guido, Cerbai, Elisabetta, Romanelli, Maria Novella
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237106/
https://ncbi.nlm.nih.gov/pubmed/30467478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01252
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