Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by t...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Dini, Leonardo, Del Lungo, Martina, Resta, Francesco, Melchiorre, Michele, Spinelli, Valentina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Laurino, Annunziatina, Sartiani, Laura, Coppini, Raffaele, Mannaioni, Guido, Cerbai, Elisabetta, Romanelli, Maria Novella
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Pharmacology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237106/
https://ncbi.nlm.nih.gov/pubmed/30467478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01252
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