Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue

BACKGROUND AND PURPOSE: Selective hyperpolarization activated, cyclic nucleotide-gated channel (HCN) blockers represent an important therapeutic goal due to the wide distribution and multiple functions of these proteins, representing the molecular correlate of f- and h-current (I(f) or I(h)). Recent...

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Detalhes bibliográficos
Main Authors: Del Lungo, Martina, Melchiorre, Michele, Guandalini, Luca, Sartiani, Laura, Mugelli, Alessandro, Koncz, Istvan, Szel, Tamas, Varro, Andras, Romanelli, Maria Novella, Cerbai, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417492/
https://ncbi.nlm.nih.gov/pubmed/22091830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01782.x
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