Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Fibroblast growth factor 21 (Fgf21) is a liver‐derived, fasting‐induced hormone with broad effects on growth, nutrient metabolism, and insulin sensitivity. Here, we report the discovery of a novel mechanism regulating Fgf21 expression under growth and fasting‐feeding. The Sel1L‐Hrd1 complex is the m...

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Udgivet i:EMBO J
Main Authors: Bhattacharya, Asmita, Sun, Shengyi, Wang, Heting, Liu, Ming, Long, Qiaoming, Yin, Lei, Kersten, Sander, Zhang, Kezhong, Qi, Ling
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236331/
https://ncbi.nlm.nih.gov/pubmed/30389665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899277
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