Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

β Cell apoptosis and dedifferentiation are 2 hotly debated mechanisms underlying β cell loss in type 2 diabetes; however, the molecular drivers underlying such events remain largely unclear. Here, we performed a side-by-side comparison of mice carrying β cell–specific deletion of ER-associated degra...

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Udgivet i:J Clin Invest
Main Authors: Shrestha, Neha, Liu, Tongyu, Ji, Yewei, Reinert, Rachel B., Torres, Mauricio, Li, Xin, Zhang, Maria, Tang, Chih-Hang Anthony, Hu, Chih-Chi Andrew, Liu, Chengyang, Naji, Ali, Liu, Ming, Lin, Jiandie D., Kersten, Sander, Arvan, Peter, Qi, Ling
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324191/
https://ncbi.nlm.nih.gov/pubmed/32182217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134874
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