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Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we report t...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6235831/ https://ncbi.nlm.nih.gov/pubmed/30429473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06813-x |
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