Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without identified functional consequences. Here we report t...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Barthet, Gaël, Jordà-Siquier, Tomàs, Rumi-Masante, Julie, Bernadou, Fanny, Müller, Ulrike, Mulle, Christophe
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235831/
https://ncbi.nlm.nih.gov/pubmed/30429473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06813-x
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