Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

BACKGROUND: In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 receptor-associated kinase 4 small molecule inhibitor (IRAK4i) affects RNA-IC-induced...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Hjorton, Karin, Hagberg, Niklas, Israelsson, Elisabeth, Jinton, Lisa, Berggren, Olof, Sandling, Johanna K., Thörn, Kristofer, Mo, John, Eloranta, Maija-Leena, Rönnblom, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235225/
https://ncbi.nlm.nih.gov/pubmed/30355354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1702-0
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