Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

BACKGROUND: In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 receptor-associated kinase 4 small molecule inhibitor (IRAK4i) affects RNA-IC-induced...

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Bibliografski detalji
Izdano u:Arthritis Res Ther
Glavni autori: Hjorton, Karin, Hagberg, Niklas, Israelsson, Elisabeth, Jinton, Lisa, Berggren, Olof, Sandling, Johanna K., Thörn, Kristofer, Mo, John, Eloranta, Maija-Leena, Rönnblom, Lars
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235225/
https://ncbi.nlm.nih.gov/pubmed/30355354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1702-0
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