Genetic interactions between the Aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis

SUMMARY: Errors in chromosome segregation during female meiosis I occur frequently, and aneuploid embryos account for 1/3 of all miscarriages in humans [1]. Unlike mitotic cells that require two Aurora kinase (AURK) homologs to help prevent aneuploidy (AURKA, AURKB), mammalian germ cells also requir...

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Udgivet i:Curr Biol
Main Authors: Nguyen, Alexandra L., Drutovic, David, Vazquez, Berta N., Yakoubi, Warif El, Gentilello, Amanda S., Malumbres, Marcos, Solc, Petr, Schindler, Karen
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234855/
https://ncbi.nlm.nih.gov/pubmed/30415701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.08.052
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