Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) is a secreted protein that has a great utility to inhibit elevated metalloproteinase (MMP) activity in injured tissues including infarcted cardiac tissue, inflamed vessels, and joint cartilages. An imbalance between TIMP3 and active MMP levels in the l...

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Vydáno v:Pharmacol Res Perspect
Hlavní autoři: Chintalgattu, Vishnu, Greenberg, Joanne, Singh, Shivani, Chiueh, Venice, Gilbert, Amy, O'Neill, Jason W., Smith, Stephen, Jackson, Simon, Khakoo, Aarif Y., Lee, TaeWeon
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234480/
https://ncbi.nlm.nih.gov/pubmed/30459952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.442
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