Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) is a secreted protein that has a great utility to inhibit elevated metalloproteinase (MMP) activity in injured tissues including infarcted cardiac tissue, inflamed vessels, and joint cartilages. An imbalance between TIMP3 and active MMP levels in the l...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Chintalgattu, Vishnu, Greenberg, Joanne, Singh, Shivani, Chiueh, Venice, Gilbert, Amy, O'Neill, Jason W., Smith, Stephen, Jackson, Simon, Khakoo, Aarif Y., Lee, TaeWeon
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234480/
https://ncbi.nlm.nih.gov/pubmed/30459952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.442
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