SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets

Platelet α-granule cargo release is fundamental to both hemostasis and thrombosis. Granule matrix hydration is a key regulated step in this process, yet its mechanism is poorly understood. In endothelial cells, there is evidence for 2 modes of cargo release: a jack-in-the-box mechanism of hydration-...

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Vydáno v:Blood Adv
Hlavní autoři: Pokrovskaya, Irina D., Joshi, Smita, Tobin, Michael, Desai, Rohan, Aronova, Maria A., Kamykowski, Jeffrey A., Zhang, Guofeng, Whiteheart, Sidney W., Leapman, Richard D., Storrie, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234365/
https://ncbi.nlm.nih.gov/pubmed/30401752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018019158
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