Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7

The neuromodulatory effects of GABA on pyramidal neurons are mediated by GABA(B) receptors (GABA(B)Rs) that signal via a conserved G-protein-coupled pathway. Two prominent effectors regulated by GABA(B)Rs include G-protein inwardly rectifying K(+) (GIRK) and P/Q/N type voltage-gated Ca(2+) (Ca(V)2)...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Ostrovskaya, Olga I., Orlandi, Cesare, Fajardo-Serrano, Ana, Young, Samuel M., Lujan, Rafael, Martemyanov, Kirill A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234300/
https://ncbi.nlm.nih.gov/pubmed/30315127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1378-18.2018
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