Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival

There is controversy concerning the role of dihydroceramide desaturase (Degs1) in regulating cell survival, with studies showing that it can both promote and protect against apoptosis. We have therefore investigated the molecular basis for these opposing roles of Degs1. Treatment of HEK293T cells wi...

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Опубликовано в: :Mol Cell Biol
Главные авторы: Alsanafi, Mariam, Kelly, Samuel L., Jubair, Karawan, McNaughton, Melissa, Tate, Rothwelle J., Merrill, Alfred H., Pyne, Susan, Pyne, Nigel J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234290/
https://ncbi.nlm.nih.gov/pubmed/30224516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00222-18
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