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Differentiating between testicular toxicity and sexual immaturity in ortho-phthalaldehyde inhalation toxicity studies in rats and mice

Early deaths of young or juvenile animals (before sexual maturation is achieved) in routine regulatory safety studies present pathologists and toxicologists with the challenge of interpreting findings in the male reproductive tract. Additionally, the advent of toxicity testing regulations have resul...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Pathol
Hauptverfasser: Catlin, Natasha R., Willson, Cynthia J., Creasy, Dianne M., Rao, Deepa B., Kissling, Grace E., McIntyre, Barry S., Wyde, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234048/
https://ncbi.nlm.nih.gov/pubmed/30259793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623318801790
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