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Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A
Efficient and highly stereoselective syntheses of cryptophycin B and arenastatin A, potent cytotoxic agents, are described. An ester-derived titanium enolate mediated syn-aldol reaction was employed to generate the stereocenters C-5 and C-6. The route is convergent and provides a convenient access t...
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| Publicado no: | European J Org Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233905/ https://ncbi.nlm.nih.gov/pubmed/30443158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.200300814 |
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