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VIPER: variability-preserving imputation for accurate gene expression recovery in single-cell RNA sequencing studies
We develop a method, VIPER, to impute the zero values in single-cell RNA sequencing studies to facilitate accurate transcriptome quantification at the single-cell level. VIPER is based on nonnegative sparse regression models and is capable of progressively inferring a sparse set of local neighborhoo...
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| Опубликовано в: : | Genome Biol |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233584/ https://ncbi.nlm.nih.gov/pubmed/30419955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1575-1 |
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