LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

BACKGROUND: Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid tr...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Feng, Mengyu, Xiong, Guangbing, Cao, Zhe, Yang, Gang, Zheng, Suli, Qiu, Jiangdong, You, Lei, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233565/
https://ncbi.nlm.nih.gov/pubmed/30419950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0947-4
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