LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

BACKGROUND: Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid tr...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Feng, Mengyu, Xiong, Guangbing, Cao, Zhe, Yang, Gang, Zheng, Suli, Qiu, Jiangdong, You, Lei, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233565/
https://ncbi.nlm.nih.gov/pubmed/30419950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0947-4
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