LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

BACKGROUND: Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid tr...

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Bibliografiske detaljer
Udgivet i:	J Exp Clin Cancer Res
Main Authors:	Feng, Mengyu, Xiong, Guangbing, Cao, Zhe, Yang, Gang, Zheng, Suli, Qiu, Jiangdong, You, Lei, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2018
Fag:	Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6233565/ https://ncbi.nlm.nih.gov/pubmed/30419950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0947-4
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LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

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