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Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8
Caspase-8 is an apoptotic protease that is activated by a proximity-induced dimerization mechanism within the death-inducing signaling complex (DISC). The death effector domain (DED) of caspase-8 is involved in protein-protein interactions and is essential for the activation. Here, we report two cry...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233201/ https://ncbi.nlm.nih.gov/pubmed/30425291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35153-5 |
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