Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

The aggregation of intracellular tau protein is a major hallmark of Alzheimer’s disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present an in-depth analysis of endogenous tau fragmentatio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Hsu-Hsin, Liu, Peter, Auger, Paul, Lee, Seung-Hye, Adolfsson, Oskar, Rey-Bellet, Lorianne, Lafrance-Vanasse, Julien, Friedman, Brad A., Pihlgren, Maria, Muhs, Andreas, Pfeifer, Andrea, Ernst, James, Ayalon, Gai, Wildsmith, Kristin R., Beach, Thomas G., van der Brug, Marcel P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233188/
https://ncbi.nlm.nih.gov/pubmed/30425303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35130-y
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