Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

Progressive aggregation of protein Tau into oligomers and fibrils correlates with cognitive decline and synaptic dysfunction, leading to neurodegeneration in vulnerable brain regions in Alzheimer's disease. The unmet need of effective therapy for Alzheimer's disease, combined with problema...

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Autori principali: Theunis, Clara, Crespo-Biel, Natalia, Gafner, Valérie, Pihlgren, Maria, López-Deber, María Pilar, Reis, Pedro, Hickman, David T., Adolfsson, Oskar, Chuard, Nathalie, Ndao, Dorin Mlaki, Borghgraef, Peter, Devijver, Herman, Van Leuven, Fred, Pfeifer, Andrea, Muhs, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747157/
https://ncbi.nlm.nih.gov/pubmed/23977276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072301
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