Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count which can cause fatal hemorrhage. ITP patients with antiplatelet glycoprotein (GP) Ib-IX autoantibodies appear refractory to conventional treatments, and the mechanism remains elusive. Here we show that the p...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Chen, Mengxing, Yan, Rong, Zhou, Kangxi, Li, Xiaodong, Zhang, Yang, Liu, Chunliang, Jiang, Mengxiao, Ye, Honglei, Meng, Xingjun, Pang, Ningbo, Zhao, Lili, Liu, Jun, Xiao, Weiling, Hu, Renping, Cui, Qingya, Zhong, Wei, Zhao, Yunxiao, Zhu, Mingqing, Lin, Anning, Ruan, Changgeng, Dai, Kesheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233141/
https://ncbi.nlm.nih.gov/pubmed/30337485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808217115
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