Protein kinase A determines platelet life span and survival by regulating apoptosis

Apoptosis delimits platelet life span in the circulation and leads to storage lesion, which severely limits the shelf life of stored platelets. Moreover, accumulating evidence indicates that platelet apoptosis provoked by various pathological stimuli results in thrombocytopenia in many common diseas...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Zhao, Lili, Liu, Jun, He, Chunyan, Yan, Rong, Zhou, Kangxi, Cui, Qingya, Meng, Xingjun, Li, Xiaodong, Zhang, Yang, Nie, Yumei, Hu, Renping, Liu, Yancai, Zhao, Lian, Chen, Mengxing, Xiao, Weiling, Tian, Jingluan, Zhao, Yunxiao, Cao, Lijuan, Zhou, Ling, Lin, Anning, Ruan, Changgeng, Dai, Kesheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707139/
https://ncbi.nlm.nih.gov/pubmed/29083324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95109
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