Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count which can cause fatal hemorrhage. ITP patients with antiplatelet glycoprotein (GP) Ib-IX autoantibodies appear refractory to conventional treatments, and the mechanism remains elusive. Here we show that the p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Chen, Mengxing, Yan, Rong, Zhou, Kangxi, Li, Xiaodong, Zhang, Yang, Liu, Chunliang, Jiang, Mengxiao, Ye, Honglei, Meng, Xingjun, Pang, Ningbo, Zhao, Lili, Liu, Jun, Xiao, Weiling, Hu, Renping, Cui, Qingya, Zhong, Wei, Zhao, Yunxiao, Zhu, Mingqing, Lin, Anning, Ruan, Changgeng, Dai, Kesheng
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233141/
https://ncbi.nlm.nih.gov/pubmed/30337485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808217115
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