Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count which can cause fatal hemorrhage. ITP patients with antiplatelet glycoprotein (GP) Ib-IX autoantibodies appear refractory to conventional treatments, and the mechanism remains elusive. Here we show that the p...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Chen, Mengxing, Yan, Rong, Zhou, Kangxi, Li, Xiaodong, Zhang, Yang, Liu, Chunliang, Jiang, Mengxiao, Ye, Honglei, Meng, Xingjun, Pang, Ningbo, Zhao, Lili, Liu, Jun, Xiao, Weiling, Hu, Renping, Cui, Qingya, Zhong, Wei, Zhao, Yunxiao, Zhu, Mingqing, Lin, Anning, Ruan, Changgeng, Dai, Kesheng
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2018
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233141/
https://ncbi.nlm.nih.gov/pubmed/30337485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808217115
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