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Computational and experimental insights into the circadian effects of SIRT1
The circadian clock orchestrates 24-h rhythms in physiology in most living organisms. At the molecular level, the dogma is that circadian oscillations are based on a negative transcriptional feedback loop. Recent studies found the NAD(+)-dependent histone deacetylase, SIRT1, directly regulates acety...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6233098/ https://ncbi.nlm.nih.gov/pubmed/30348778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803410115 |
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