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KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood. Here, we report that KPNB1, an importin β component of the ncRNA repressor of nuclear fac...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lee, Yool, Jang, A Reum, Francey, Lauren J, Sehgal, Amita, Hogenesch, John B
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597257/
https://ncbi.nlm.nih.gov/pubmed/26319354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08647
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