Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects

Neurodegenerative disorders, such as Huntington’s diseases and spinocerebellar ataxias (SCAs), are driven by proteins with expanded polyglutamine (polyQ) tracts. Recently, coiled-coil structures in polyQ regions of such proteins were shown to facilitate aggregate formation and ultimately lead to cel...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kwon, Min Jee, Han, Myeong Hoon, Bagley, Joshua A., Hyeon, Do Young, Ko, Byung Su, Lee, Yun Mi, Cha, In Jun, Kim, Seung Yeol, Kim, Dong Young, Kim, Ho Min, Hwang, Daehee, Lee, Sung Bae, Jan, Yuh Nung
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233066/
https://ncbi.nlm.nih.gov/pubmed/30348793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807206115
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