Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects

Neurodegenerative disorders, such as Huntington’s diseases and spinocerebellar ataxias (SCAs), are driven by proteins with expanded polyglutamine (polyQ) tracts. Recently, coiled-coil structures in polyQ regions of such proteins were shown to facilitate aggregate formation and ultimately lead to cel...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kwon, Min Jee, Han, Myeong Hoon, Bagley, Joshua A., Hyeon, Do Young, Ko, Byung Su, Lee, Yun Mi, Cha, In Jun, Kim, Seung Yeol, Kim, Dong Young, Kim, Ho Min, Hwang, Daehee, Lee, Sung Bae, Jan, Yuh Nung
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233066/
https://ncbi.nlm.nih.gov/pubmed/30348793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807206115
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