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Correlation of CRM1-NES affinity with nuclear export activity

CRM1 (Exportin1/XPO1) exports hundreds of broadly functioning protein cargoes out of the cell nucleus by binding to their classical nuclear export signals (NESs). The 8- to 15-amino-acid-long NESs contain four to five hydrophobic residues and are highly diverse in both sequence and CRM1-bound struct...

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Pubblicato in:Mol Biol Cell
Autori principali: Fu, Szu-Chin, Fung, Ho Yee Joyce, Cağatay, Tolga, Baumhardt, Jordan, Chook, Yuh Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232958/
https://ncbi.nlm.nih.gov/pubmed/29927350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-02-0096
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