Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic properties in diet-induced obese mice. However, the...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Li, Mingxin, Zhang, Yemin, Cao, Yingkang, Zhang, Deling, Liu, Le, Guo, Yanghongyun, Wang, Changhua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232724/
https://ncbi.nlm.nih.gov/pubmed/30459603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01180
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