Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic properties in diet-induced obese mice. However, the...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Li, Mingxin, Zhang, Yemin, Cao, Yingkang, Zhang, Deling, Liu, Le, Guo, Yanghongyun, Wang, Changhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232724/
https://ncbi.nlm.nih.gov/pubmed/30459603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01180
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