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PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes

OBJECTIVE: The involvement of phosphodiesterase type 5 (PDE5) in the development of insulin resistance has been reported recently. However, the underlying molecular mechanism remains unclear. The present study aims at investigating the potential impacts of PDE5A on insulin signaling in C2C12 skeleta...

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Podrobná bibliografie
Vydáno v:Int J Endocrinol
Hlavní autoři: Liu, Wei, Tian, Xiaojun, Wu, Ti, Liu, Le, Guo, Yanghongyun, Wang, Changhua
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350610/
https://ncbi.nlm.nih.gov/pubmed/30774657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3054820
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