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PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes

OBJECTIVE: The involvement of phosphodiesterase type 5 (PDE5) in the development of insulin resistance has been reported recently. However, the underlying molecular mechanism remains unclear. The present study aims at investigating the potential impacts of PDE5A on insulin signaling in C2C12 skeleta...

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Bibliografske podrobnosti
izdano v:Int J Endocrinol
Main Authors: Liu, Wei, Tian, Xiaojun, Wu, Ti, Liu, Le, Guo, Yanghongyun, Wang, Changhua
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350610/
https://ncbi.nlm.nih.gov/pubmed/30774657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3054820
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