Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy

OBJECTIVE: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The ai...

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Detaylı Bibliyografya
Yayımlandı:Chin J Cancer Res
Asıl Yazarlar: Pereira, Marina Alessandra, Ramos, Marcus Fernando Kodama Pertille, Dias, Andre Roncon, Faraj, Sheila Friedrich, Cirqueira, Cinthya dos Santos, de Mello, Evandro Sobroza, Zilberstein, Bruno, Alves, Venancio Avancini Ferreira, Ribeiro Jr., Ulysses
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: AME Publishing Company 2018
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232357/
https://ncbi.nlm.nih.gov/pubmed/30510364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21147/j.issn.1000-9604.2018.05.06
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