Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy

OBJECTIVE: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The ai...

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Dettagli Bibliografici
Pubblicato in:Chin J Cancer Res
Autori principali: Pereira, Marina Alessandra, Ramos, Marcus Fernando Kodama Pertille, Dias, Andre Roncon, Faraj, Sheila Friedrich, Cirqueira, Cinthya dos Santos, de Mello, Evandro Sobroza, Zilberstein, Bruno, Alves, Venancio Avancini Ferreira, Ribeiro Jr., Ulysses
Natura: Artigo
Lingua:Inglês
Pubblicazione: AME Publishing Company 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232357/
https://ncbi.nlm.nih.gov/pubmed/30510364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21147/j.issn.1000-9604.2018.05.06
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