Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy

OBJECTIVE: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The ai...

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Detalhes bibliográficos
Publicado no:Chin J Cancer Res
Main Authors: Pereira, Marina Alessandra, Ramos, Marcus Fernando Kodama Pertille, Dias, Andre Roncon, Faraj, Sheila Friedrich, Cirqueira, Cinthya dos Santos, de Mello, Evandro Sobroza, Zilberstein, Bruno, Alves, Venancio Avancini Ferreira, Ribeiro Jr., Ulysses
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232357/
https://ncbi.nlm.nih.gov/pubmed/30510364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21147/j.issn.1000-9604.2018.05.06
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