Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: polymorphisms, structure, and function of complement receptor 1

INTRODUCTION: Genome-wide association studies consistently show that single nucleotide polymorphisms (SNPs) in the complement receptor 1 (CR1) gene modestly but significantly alter Alzheimer’s disease (AD) risk. Follow-up research has assumed that CR1 is expressed in human brain, despite a paucity o...

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Pubblicato in:Alzheimers Dement
Autori principali: Johansson, Jenny U., Brubaker, William D., Javitz, Harold, Bergen, Andrew W., Nishita, Denise, Trigunaite, Abhishek, Crane, Andrés, Ceballos, Justine, Mastroeni, Diego, Tenner, Andrea J., Sabbagh, Marwan, Rogers, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231989/
https://ncbi.nlm.nih.gov/pubmed/29792870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2018.04.003
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