Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: 2. Relationship to Aβ immunotherapy

INTRODUCTION: Our previous studies have shown that amyloid β peptide (Aβ) is subject to complement-mediated clearance from the peripheral circulation, and that this mechanism is deficient in Alzheimer’s disease (AD). The mechanism should be enhanced by Aβ antibodies, which form immune complexes (ICs...

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Publicat a:Alzheimers Dement
Autors principals: Crane, Andrés, Brubaker, William D., Johansson, Jenny U., Trigunaite, Abhishek, Ceballos, Justine, Bradt, Bonnie, Glavis-Bloom, Courtney, Wallace, Tanya L., Tenner, Andrea J., Rogers, Joseph
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881571/
https://ncbi.nlm.nih.gov/pubmed/28755839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2017.04.015
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