Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus

The control of virulence regulator/sensor kinase (CovRS) two-component system is critical to the infectivity of group A streptococcus (GAS), and CovRS inactivating mutations are frequently observed in GAS strains causing severe human infections. CovS modulates the phosphorylation status and with it...

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Udgivet i:PLoS Pathog
Main Authors: Horstmann, Nicola, Tran, Chau Nguyen, Brumlow, Chelcy, DebRoy, Sruti, Yao, Hui, Nogueras Gonzalez, Graciela, Makthal, Nishanth, Kumaraswami, Muthiah, Shelburne, Samuel A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231683/
https://ncbi.nlm.nih.gov/pubmed/30379939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007354
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