Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

BACKGROUND: Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibrils via oligomers from monomers. Aβ has been reported to activate the NLRP3 infla...

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Detalhes bibliográficos
Publicado no:Inflamm Regen
Main Authors: Nakanishi, Ayaka, Kaneko, Naoe, Takeda, Hiroyuki, Sawasaki, Tatsuya, Morikawa, Shinnosuke, Zhou, Wei, Kurata, Mie, Yamamoto, Toshihiro, Akbar, Sheikh Mohammad Fazle, Zako, Tamotsu, Masumoto, Junya
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231249/
https://ncbi.nlm.nih.gov/pubmed/30459926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41232-018-0085-6
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