Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases

The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial role in interleukin-1 maturation or specific physiological functions. Two Nod-like receptors,...

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Detalhes bibliográficos
Publicado no:Inflamm Regen
Main Authors: Kaneko, Naoe, Iwasaki, Tomoyuki, Ito, Yuki, Takeda, Hiroyuki, Sawasaki, Tatsuya, Morikawa, Shinnosuke, Nakano, Naoko, Kurata, Mie, Masumoto, Junya
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725934/
https://ncbi.nlm.nih.gov/pubmed/29259708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41232-017-0040-y
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