IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation

Recent findings revealed that type 2 diabetes mellitus (T2D) is a chronic inflammatory disease and an islet amyloid polypeptide (IAPP)/amylin, is deposited within pancreatic islets. IAPP/amylin has been reported to activate NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in inf...

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Detalhes bibliográficos
Publicado no:Int J Immunopathol Pharmacol
Main Authors: Morikawa, Shinnosuke, Kaneko, Naoe, Okumura, Chikara, Taguchi, Haruka, Kurata, Mie, Yamamoto, Toshihiro, Osawa, Haruhiko, Nakanishi, Ayaka, Zako, Tamotsu, Masumoto, Junya
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050799/
https://ncbi.nlm.nih.gov/pubmed/30014749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2058738418788749
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