Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins

Low–molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant activity is not fully reversible by protamine. Furthermore, the reliability of the LMWH supply chain is a concern for regula...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Xu, Yongmei, Chandarajoti, Kasemsiri, Zhang, Xing, Pagadala, Vijayakanth, Dou, Wenfang, Hoppensteadt, Debra Moorman, Sparkenbaugh, Erica M., Cooley, Brian, Daily, Sharon, Key, Nigel S., Severynse-Stevens, Diana, Fareed, Jawed, Linhardt, Robert J., Pawlinski, Rafal, Liu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231235/
https://ncbi.nlm.nih.gov/pubmed/28878012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan5954
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